After retiring from professional baseball in 2013, Seth Etherton transitioned into coaching. His deep understanding of pitching, player development, and the nuances of the game quickly made him a respected figure in coaching circles. Etherton began his coaching career in the college ranks at the University of San Francisco, where he brought his expertise to young, aspiring players in 2014 and 2015.

In 2016, he joined the Cincinnati Reds organization as a pitching coach, where he would spend the next seven years working with a variety of players at different levels of the minor league system. Etherton’s deep understanding of pitching mechanics, mental toughness, and strategy made him an asset to the Reds’ player development program. Etherton played a crucial role in assisting his pitchers with the challenges of managing pressure, adjusting their approach against tougher hitters, and refining their skills. His ability to work with pitchers on both a technical and psychological level made him a trusted figure among players and staff.

Etherton’s coaching tenure culminated in his role as the pitching coach for the Louisville Bats, the Reds' AAA affiliate. This was a pivotal position where Etherton worked closely with some of the top prospects in the Reds system, preparing them for potential call-ups to the Major League roster. At this level, Etherton’s focus was on honing pitchers’ advanced skills, improving pitch selection, and helping them make adjustments that could contribute to their success at the Major League level. His expertise in working with pitchers on the cusp of the big leagues was crucial in helping them refine their mechanics and maintain their confidence under pressure.

One of his most significant coaching roles came at the University of Southern California (USC), where he became the pitching coach for the USC Trojans in the fall 0f 2022. In this role, Etherton used his vast experience to mentor and develop pitchers, helping them refine their skills, improve their deliveries, and thrive in competitive environments. His coaching philosophy emphasizes discipline, technique, and the mental aspect of the game, all of which he believes are crucial for long-term success.

Etherton’s coaching style is often described as a combination of high expectations, strong communication, and an understanding of the personal and technical aspects of each player's journey. He has proven himself to be a coach who builds lasting relationships with his players, helping them not only improve their skills but also navigate the challenges of a highly competitive sport.